Toxicity of 1,2-dimethylhydrazine in Mice: Effect of Diet and Development of Tolerance
نویسندگان
چکیده
The effect of diet on the lethality of 1, 2-dimethylhydrazine (DMH) injec tions was investigated using Swiss mice. Mortality was highest when mice were fed a nutrient-dilutealfhigh-fat diet, was intermediate with a nutrientdilutealflow-fat diet and was lowest with laboratory chow. Wheat bran was not protective. Mice developed tolerance to DMH after receiving several injections of progressively increasing dose.
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